I would like to see more studies done like this, I think this is important for people and animals. I am aghast we didn't do many, of any, of these types of studies a hundred years or so ago. Er, how long has science been around? ;) Why do humans assume they know things that frankly is just hearsay or seems common sense or has been handed down? All those things do not mean something is an actual fact.
Food intake is regulated primarily by dietary protein and carbohydrate
Low-protein, high-carbohydrate diets are associated with the longest lifespans
Energy reduction from high-protein diets or dietary dilution does not extend life
Diet influences hepatic mTOR via branched-chain amino acids andglucose
The fundamental questions of what represents a macronutritionally balanced diet and how this maintains health and longevity remain unanswered. Here, the Geometric Framework, a state-space nutritional modeling method, was used to measure interactive effects of dietary energy, protein, fat, and carbohydrate on food intake, cardiometabolic phenotype, and longevity in mice fed one of 25 diets ad libitum. Food intake was regulated primarily by protein and carbohydrate content. Longevity and health were optimized when protein was replaced with carbohydrate to limit compensatory feeding for protein and suppress protein intake. These consequences are associated with hepatic mammalian target of rapamycin(mTOR) activation and mitochondrial function and, in turn, related to circulating branched-chain amino acids and glucose. Calorie restriction achieved by high-protein diets or dietary dilution had no beneficial effects on lifespan. The results suggest that longevity can be extended in ad libitum-fed animals by manipulating the ratio of macronutrients to inhibit mTOR activation.
Trying to live sustainably in my new tiny hobby farm in the Appalachia foothills... 2 donkeys,lotsa chickens, a dog and a cat. And a 4-wheeler WHEEE! Goats are next once we get more goat-proof fencing LOL! Also some bits of cooking, political commentary, and microbiology. Varied interests make for an intriguing mind :)