Surprising results

I would like to see more studies done like this, I think this is important for people and animals. I am aghast we didn't do many, of any, of these types of studies a hundred years or so ago. Er, how long has science been around? ;)  Why do humans assume they know things that frankly is just hearsay or seems common sense or has been handed down? All those things do not mean something is an actual fact.

 

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Cell Metabolism, Volume 19, Issue 3, 418-430, 4 March 2014
Copyright © 2014 Elsevier Inc. All rights reserved.
10.1016/j.cmet.2014.02.009

Authors

Samantha M. Solon-Biet,Aisling C. McMahon,J. William O. Ballard,Kari Ruohonen,Lindsay E. Wu,Victoria C. Cogger,Alessandra Warren,Xin Huang,Nicolas Pichaud,Richard G. Melvin,Rahul Gokarn,Mamdouh Khalil,Nigel Turner,Gregory J. Cooney,David A. Sinclair,David Raubenheimer,David G. Le Couteur,Stephen J. SimpsonSee Affiliations

• Highlights
• Food intake is regulated primarily by dietary protein and carbohydrate
• Low-protein, high-carbohydrate diets are associated with the longest lifespans
• Energy reduction from high-protein diets or dietary dilution does not extend life
• Diet influences hepatic mTOR via branched-chain amino acids andglucose

Summary

The fundamental questions of what represents a macronutritionally balanced diet and how this maintains health and longevity remain unanswered. Here, the Geometric Framework, a state-space nutritional modeling method, was used to measure interactive effects of dietary energy, protein, fat, and carbohydrate on food intake, cardiometabolic phenotype, and longevity in mice fed one of 25 diets ad libitum. Food intake was regulated primarily by protein and carbohydrate content. Longevity and health were optimized when protein was replaced with carbohydrate to limit compensatory feeding for protein and suppress protein intake. These consequences are associated with hepatic mammalian target of rapamycin(mTOR) activation and mitochondrial function and, in turn, related to circulating branched-chain amino acids and glucose. Calorie restriction achieved by high-protein diets or dietary dilution had no beneficial effects on lifespan. The results suggest that longevity can be extended in ad libitum-fed animals by manipulating the ratio of macronutrients to inhibit mTOR activation.